In this study, a 3D finite element model of an intact mandible was used for the simulation of the movement of the lower jaw and analysis of the effects of TemporoMandibular Joint (TMJ) prosthesis replacement on the jaw movement. Seven bundles of muscle fibers were inserted in their appropriate positions following anatomical data. Digastric, geniohyoid and lateral pterygoid muscles were considered for opening the mouth while medial pterygoid, superficial masseter, deep masseter and temporalis muscles were used for closing the mouth. Then, the TMJ was replaced by two different types of TMJ prostheses in the same way as in a surgery operation. One of the prostheses was designed based on anatomical shape of the ramus and condyle of the mandible while the other one was taken similar to the commercial TMJ prostheses. Eventually, all three models underwent an opening jaw simulation and produced an identical range of motion while were mismatched in other parameters. The results show that since the anatomical TMJ prosthesis resembles the shape and structure of an intact mandible; therefore, it is more capable of simulating the motion of mandible compared to the commercial TMJ prosthesis. Furthermore, better contact between the anatomical TMJ prosthesis and the mandible leads to lower stress distribution in comparison with the commercial TMJ implant. Finally, as the amount of muscle forces and strain in anatomical TMJ prosthesis replacement are less than the commercial one, the patient needs to make less effort to move the mandible and open the mouth.