The purpose of conducting this research is to establish a conceptual model to improve the performance of new product development in organizations regarding variables of disruptive innovation, team vision, knowledge management, and fuzzy-front end. In this research, the structural equation modelling (SEM) is used to study the model. Also, the explanatory and confirmatory factor analysis are used to extract dimensions of fuzzy-front end and disruptive innovation variables. Research data have been gathered from 109 experts of development and research department of Iran Khodro manufacturing company. The results of research show that disruptive innovation may have very impressive effects on new product development performance. Also, team approach has direct effect on fuzzy-front end. On the other hand, knowledge management has a key role in new product development and organizations can increase the efficiency of new product development by managing their knowledge and sharing them and guarantee the organization success.