Supply chain management (SCM) plays a major role in allowing manufacturing companies to achieve competitive advantage. However, only few studies have been investigated in manufacturing industry, particularly on the relationship between SCM drivers and competitive advantage. Therefore, the objective of this study is to explore the impact of supply chain management drivers on competitive advantage in Vietnamese manufacturing companies. By adopting the exploratory factor analysis (EFA), a multiple regression analysis, the author finds out that the SCM drivers including facilities, inventory, transportation, information, sourcing and pricing are strongly related to competitive advantage in the manufacturing. The results contribute to the current literature on supply chain and they are essential for supply chain in manufacturing industry by acknowledging the influence of SCM drivers on competitive advantage.