The aim of this research is to understand the effect of product quality, medical price and staff skill on patient’s loyalty through cultural impact in medical tourism. In this study, three exogenous con-structs; namely product quality, medical price, and staff skill constructs were adopted to find their effects on patient’s loyalty. Meanwhile, the cultural impact is also adopted as a mediator construct. This study uses confirmatory approach as Covariance based Structural Equation Modeling (CBSEM) for testing the research hypotheses. The study explores inbound medical tourists loyalty from 324 respondents sampled comprised from different countries using stratified sampling. In terms of the direct effect, the method reveals that medical price and staff skill had positive significant effects on cultural impact and patient loyalty. In terms of indirect effect, the cultural impact mediates the relationships between product quality, medical price, and staff skills on patient’s loyalty.