Knowledge management plays an essential role on achieving business success and it is considered as intangible attests for many organizations. In fact, many people believe intangible assets are the most influential part of any firm’s investment. This paper investigates the relationships among four variables including empowering leadership, task technology fit, compatibility and knowledge management system (KMS). The study considers whether there is any positive relationship between empowering leadership and task technology fit, between empowering leadership and compatibility, between task technology fit and KMS usage and between compatibility and KMS usage. The survey selects a sample of 215 people from the regular employees as well as university professors of Islamic research center of Qom province, Iran. We have distributed 220 questionnaires and collected 160 for the investigation. The results of this survey indicate that there is a meaningful and positive relationship between empowering leadership and compatibility (0.72, t-student=4.01), a meaningful and positive relationship between empowering leadership and compatibility (0.80, t-student=4.64), a positive and meaningful relationship between task technology fit and KMS usage (0.72, t-student=3.58) and finally there is a positive and meaningful relationship between compatibility and KMS usage (0.43, t-student=2.78).