Researchers have tried to investigate multiple factors affecting employees & apos; social, emotional, and psychological well-being. In this study particularly, nurses & apos; emotional and psychological well-being is considered. Of most important factors affecting well-being in place of work has known to be busy work and stress, constructive and destructive emotions, and psychological capital which. Present study considered to test a developed model of psychological capital, constructive and destructive emotions, stress, anxiety, and depression as antecedents of well-being. 296 nurses took part in the survey, using path analysis method hypotheses were tested, and the proposed model was evaluated. Results indicated that nurses & apos; high psychological capital increases their constructive emotions, reduces destructive emotions and eventually increase their well-being. The role of destructive emotions was more prominent in increasing wellbeing as well. Furthermore, stress had an incremental influence on well-being. In general, research results emphasize the need for more attention to the components of psychological capital, and intervention and coping strategies. The conclusions of a more detailed is that to improve nurses & apos; well-being the more emphasize should be on decreasing destructive emotions than increasing constructive ones. In addition, keeping an optimal level of stress is necessary for good functioning and improvement of overall well-being.