The objective of the article is to assess the influence of corporate social responsibility and Government environmental regulation on sustainable growth and development of Vietnamese seafood enterprises. Data was collected for 3 months with valid votes for analysis of 658 enterprises. The results show that both social responsibility, government environmental regulation, and ecosystem innovation strategies have a statistically significant positive impact on Enterprise sustainable business growth of Vietnamese seafood enterprises. At the same time, the ecosystem innovation strategies are fully mediating in the relationship between Government environmental regulation and Enterprise sustainable business growth.