This study aims to find empirical evidence regarding the factors that affect the quality of information systems and the quality of supply chain management as seen from the environmental uncertainty of the organizational structure and the distribution network competence in manufacturing companies in Medan, Indonesia. The research method used is quantitative and verification that aims to determine the relationship between variables through a hypothesis testing. The data used are primary data using a questionnaire aimed at functional managers of marketing managers and production managers with a Likert scale. The study uses a sampling technique through a census of the entire population as a unit of analysis as many as 206 managers spread across 103 manufacturing companies in the city of Medan. Data analysis was performed through multiple linear regression analysis. The results showed that environmental uncertainty, organizational structure, and distribution network competence partially and simultaneously affected the quality of supply chain management information systems in manufacturing companies.