The purpose of this paper is to present the relief operations (RO), responding to a sudden, natural, national disaster (SNND) as a multi-mode resource-constrain multi-project scheduling problem (MRCMPSP). A conceptual framework at a strategic level is constructed and the Colombian RO for an earthquake response is shown as an illustrative case. We concluded that RO can be addressed as a MRCMPSP and that for Colombian case, it is a convenient way to board it. Addressing RO as a MRCMPSP allows managers to implement different project scheduling tools successful in other contexts.