Nowadays, the significant demand for concrete has become a problem in concrete using aggregate from waste. Using standard concrete is recommended to reduce the breakdown of buildings. Unfortunately, standard materials used to produce previous concrete are not entirely environmentally friendly. As a result, many researchers have committed their awareness to identifying eco-friendlier substitutions in manufacturing concrete substitution aggregate from waste. In this respect, this paper discussed the proposed efficient procedure to indicate the compressive strength from mixed proportioning cockle shell, glass powder, and epoxy resin as concrete under hot water curing conditions (60°C, 4 hr) using response surface methodology. The experimental design used in this research uses a response surface methodology. There are three aggregates to be investigated, namely cockle shell powder, glass powder and epoxy resin under hot water curing condition (60°C, 4 hr). Under hot water curing conditions, this research discovered that adding 4.0% cockle shell powder and 10.0 % glass powder increased the compressive strength to 104.68 MPa. On the other hand, 4.0% cockle shell powder, 10.0% glass powder and 2% epoxy resin under hot water curing conditions improved the compressive strength to 115.70 MPa. It was therefore inferred that the use of both cockle shell powder and glass powder to produce cleaner and compressive strength concrete is applicable, both mechanically and environmentally.