A number of 5-dichloromethylidene-4-sulfonyliminohydantoins were synthesized by the reaction of 2-amino-3,3-dichloroacrylonitrile (ADAN) with aryl and alkyl isothiocyanates. These products are polyfunctional molecules that are considered as initial materials for the synthesis of bioactive compounds. The method of such derivatives multigram synthesis was optimized; also, the features of purification were described, and the main products of reaction mixture alcoholysis (acyclic carbamates) were identified for the first time. A number of modifications was carried out on the example of 5-dichloromethylidene-4-tosyliminohydantoin, namely: alkylation, hydrolysis of the amino group with subsequent arylation, substitution reaction with S-nucleophile, Suzuki – Miyaura coupling, and reduction of the dichloromethylidene fragment to the methyl group. The anticancer activity of 5-dichloromethylidene-4-tosyliminohydantoin was shown.

Spodopetra Frugiperda is a highly polyphagous migratory lepidopteran pest species. It causes infestation in crops leading to severe crop losses. Being a new invasive parasite, its susceptibility to insecticides needs to be explored and therefore, there is an urgent need to develop the potent insecticides for the effective control of this insect pest. This is the first report on toxic effects produced by the prepared chalcone and hydrazone analogs, followed by structure relationships. Five compounds of chalcone and hydrazone derivatives have been synthesized in pure state as reported procedures, and their toxicity as potential insecticidal agent against Spodopetra Frugiperda was screened. Their characterizations by using spectroscopic analyses were performed. The toxicity data exhibited that compound 5 is more toxic about 2-fold than other synthesized compounds, the other screened compounds showed weak to strong toxicological activity against Spodopetra Frugiperda (lepidoptera: Noctuidae).