This paper presents the results of research on the vibration of the Hyundai Universe bus using an air suspension system and mechanical suspension system when it is run at different speeds on random road surface profiles according to ISO 8608:2016. The research results show that the used air suspension system ensures smooth movement and dynamic safety according to TCVN 6964:2008 (ISO 2631:2003) and VDI 2057:2017 standards. The maximum vehicle speeds on different road classes varied from 105km/h to 65km/h. A vehicle with an air suspension system provided a smaller root mean square of vibration acceleration RMS(Z) than a vehicle with a mechanical suspension system. The root means square of the wheel load RMS(Fz) of a vehicle with an air suspension system is about 99.6% of that of a vehicle with a mechanical suspension system.