Academic failure is one of the most important issues in educational systems and there are several attempts held to prevent such issues. In this paper, we study the relationship between school connection and academic failure among some high schools students in city of Esfahan, Iran during the academic calendar of 2011-2012. The study chooses a sample of 377 students based on clustering sampling technique and using Pearson correlation test as well as stepwise multiple regression technique, the relationship between school connection and academic failure is investigated. The result of Pearson correlation ratio indicates that there is meaningful relationship between these two components. In addition, the result of regression analysis indicates that 32% of students’ academic failure is determined by this ratio.