Supply chain integration is a key factor in improving business performance. Despite this growing interest, little research has highlighted this issue that will determine the survival of many companies. The purpose of this study was to examine the relationship between the supply chain integration practices (SCMP) and the financial and operational performance of Tunisian manufacturing companies. To achieve this, a questionnaire was used as a research tool for data collection. Multiple regression analysis using SPSS26 software was used to answer study questions and examine study hypotheses. According to research, SCMP includes customer relationship management (CRM), supplier relationship management (SRM), buyer-supplier collaboration (BSC), joint knowledge creation (JCK), level of information sharing (IS), goal congruence (GC) , risk management (RM), internet usage (IU), quality management (QM) , except information quality (IQ), collaborative planning, forecasting and replenishment practices (CPFR), and just-in-time (JIT), are all significantly related to the financial and operational performance of the companies surveyed. Some recommendations are proposed to help managers better manage knowledge throughout the supply chain.