The objective of this paper is to assess the impact of corporate social responsibility (CSR) on organizational commitment (OC) through organizational trust and organizational identification in Vietnamese pharmaceutical enterprises. The survey results are based on 289 Vietnamese pharmaceutical enterprises, and the results show that CSR activities and policies had a positive impact on organization trust in the organization and positively impact on organizational identification and organizational commitment. Next, the study also conducts a mediate role of organizational trust and organizational identification. The testing results show that organizational trust and organizational identification had a comprehensive mediate role on the relationship between CSR and OC in Vietnamese pharmaceutical enterprises.