By the reaction of substituted benzaldehydes and indol-3-carbaldehydes (2E)-2-cyano-N-[5-(R-benzyl)-1,3-thiazol-2-yl]-3-(R1-phenyl)prop-2-enamides 3-(1-R1-1H-indol-3-yl)-2-cyano-N-(5-(R-benzyl)-1,3-thiazol-2-yl)prop-2-enamides were synthesised. The antitumor activity of prepared compounds were investigated. 3-(1-Benzyl-1H-indol-3-yl)-2-cyano-N-(5-(2-chlorobenzyl)-1,3-thiazol-2-yl)prop-2-enamide (7b) has been identified as hit compound with values of MG-MID GI50 = 3.903 µM, TGI = 29.10 µM, LC50 = 57.54 µM.
Growing Science » Authors » Liybov Kostyshyn
1. 
Synthesis and antitumor activity of 2-cyanocinnamic acid amides and their indole analogues Pages 119-128
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Authors: Yuliia Matiichuk, Iryna Drapak, Serhii Kramarenko, Yana Drapak, Liybov Kostyshyn, Nataliya Shtoyko, Vasyl Matiychuk
Keywords: Acrylonitrile, Thiazole, Indole, Knoevenagel reaction, Anticancer Activity
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Journal: CCL | Year: 2025 | Volume: 14 | Issue: 1 | Views: 85 | Reviews: 0