The purpose of this study is to examine the relationships of master production scheduling (MPS), total quality management (TQM), blood production (BP) and blood transfusion sustainability in the blood bank sector of Uganda. This study considers MPS as an independent variable and examines its relationship with BTS through TQM and BP. Based on the dynamic capability theory, this study concurrently incorporates and considers TQM and BP as independent and serial mediators. Data was collected from 213 blood bank respondents using a self-administered questionnaire. Random simple sampling was used to draw the sample. SEM approach was used in the study to assess the model. The major findings are positive total effect relationship between MPS and BTS; BP was found to be an independent mediator, TQM was found not to be an independent mediator, and TQM and BP mediated the MPS and BTS relationship serially. The findings suggest that MPS is related to BTS through a serial mediation model with two mediators. Therefore, blood banks in Uganda need to pay attention to develop and maintain a better MPS program so that positive perceptions of blood transfusion can be attained. Future research should investigate the mediating effect of other TQM and BP dimensions in the link between MPS and BTS in other countries.