The integration between production and distribution to minimize total elapsed time is an important issue for industries that produce products with a short lifespan. However, the literature focus on production environments with a single stage. This paper enhances the complexity of the production system of an integrated production and distribution system by considering flowshop environment decisions integrated with a vehicle routing problem decision. In this case, each order is produced in a permutation flowshop subsystem and then shipped to its destination by a capacitated vehicle, and the objective is to sequence these orders to minimize the makespan of the schedule. This paper uses two approaches to address this integrated problem: a mixed-integer formulation and an Iterated Greedy algorithm. The experimentation shows that the Iterated Greedy algorithm yields results with a 0.02% deviation from the optimal for problems with five jobs, and is a viable option to be used in practical cases due to its short computational time.