Innovation is one of the key factors distinguishing organizations from competitors in today’s high-ly competitive markets. Therefore, improving innovative performance is critical for creating com-petitive advantage. On the other hand, availability of information and knowledge can be defined as one the best ways to increase the innovation ability of organizations. Many theorists as well as practitioners emphasize on knowledge management as an enabler in enhancing organizational inno-vation. Hence, This study is carried out in the Fars governor in Iran during the year of 2017 to in-vestigate the relationship between the knowledge-based leadership and knowledge management and innovation performance. This study is descriptive / survey and the data collection is a cross-sectional and data questionnaire is used to collect the required data. Data analysis and hypotheses testing have indicated a significant relationship between knowledge-based leadership and knowledge management and innovation performance in Fars governor. The results also suggest a relationship between knowledge-based leadership and the knowledge management activities with a coefficient of 0.97. In addition, There is also a positive and meaningful relationship between knowledge management and innovation performance with a coefficient of 0.73 and between knowledge-based leadership and innovation performance with a coefficient of 0.73. The results al-so led to the existence of a relationship between knowledge based leadership, knowledge manage-ment practices and innovation performance with a coefficient of 0.7081.