Banking system plays an important role in boosting the economy and when they become profitable, they could help industries more efficiently. The proposed study of this paper attempts to investigate the effects of operating risk and capital structure on profitability of banking industry. The proposed study of this paper includes 17 commercial banks, which were active from 2006 to 2010 in Iran and the results of the study indicate that although there was a positive relationship between capital structure and profitability but there was no meaningful relationship between operating risk and capital structure. In addition, the results of our study mention that operating risks negatively impacts profitability and economic figures do not have any influence on profitability, operating risks and capital structure.