The study proposed a multi-criterion decision model from benefit, opportunity, cost, risk aspects of SME family business to develop logical investment priorities for northeast Indian family entrepreneurs. The data was collected from 368 northeast entrepreneurs and analytical hierarchy process was applied to develop weights and priorities of every criteria and sub-criteria. The study found employment opportunity; business growth; reputation; stability and succession planning as top priorities. The findings provide heuristic judgment for entrepreneurs and infer to entrepreneurs while taking strategic investment decisions and also to local governments, policymakers, and industrialists. Further, the limitations and research directions were presented.