In recent years, there have been significant changes on governmental agencies than any other organizations. There is also an agreement that any improvement on economy requires an efficient government. Governments must be responsive against their people and society but there are evidences that many governmental agencies are not able to meet people’s needs despite access to financial resources because of lack of entrepreneurial approach. This paper presents an empirical investigation to study the role of entrepreneurship governmental groups on macro-economic strategies. The study uses structural equation modeling, by designing a questionnaire in Likert scale, and distributes it among 384 randomly selected university professors in city of Tehran, Iran. The results confirm that technology-based economy, creative human resources and training, competition in the economic environment, knowledge creation, dissemination and application and promoting a culture of innovation and entrepreneurship influence positively on entrepreneurship governmental groups. In addition, the positive effects of entrepreneurship governmental groups on national commitment and management are confirmed.