A dynamic system differs from a static system in that it contains signal factor and the target value depends on the level of the signal factor set by the system operator. The aim of optimizing a multi-response dynamic system is to find a setting combination of input controllable factors that would result in optimum values of all response variables at all signal levels. The most commonly used performance metric for optimizing a multi-response dynamic system is the composite desirability function (CDF). The advantage of using CDF is that it is a simple unit less measure and it has a good foundation in statistical practice. However, the problem with the CDF is that it does not consider the variability of the individual response variables. Moreover, if the specification limits for the response variables are not provided the CDF cannot be computed. In this paper, a new performance metric for multi-response dynamic system, called multiple regression-based weighted signal-to-noise ratio (MRWSN) is proposed, which overcome the limitations of CDF. Two sets of experimental data on multi-response dynamic systems, taken from literature, are analysed using both CDF-based and the proposed MRWSN-based approaches for optimization. The results show that the MRWSN-based approach also results in substantially better optimization performance than the CDF-based approach.