A sequential production line is defined as a set of sequential operations within a factory or distribution center whereby entities undergo one or more processes to produce a final product. Sequential production lines may gain efficiencies such as increased throughput or reduced work in progress by utilizing specific configurations while maintaining the chronological order of operations. One problem identified by the authors via a case study is that, some of the configurations, such as work cell or U-shaped production lines that have groups of buffers, often increase the space utilization. Therefore, many facilities do not take advantage of the configuration efficiencies that a work cell or U-shaped production line provide. To solve this problem, the authors introduce the concept of a buffer cluster. The production line implemented with one or more buffer clusters maintains the throughput of the line, identical to that with dedicated buffers, but with the clusters reduces the buffer storage space. The paper derives a time based parametric model that determines the sizing of the buffer cluster, provides a reduced time space for which to search for the buffer cluster sizing, and determines an optimal buffer clustering policy that can be applied to any N-server, N+1 buffer sequential line configuration with deterministic processing time. This solution reduces the buffer storage space utilized while ensuring no overflows or underflows occur in the buffer. Furthermore, the paper demonstrates how the buffer clustering policy serves as an input into a facility layout tool that provides the optimal production line layout.