Asphaltic concrete mixtures are among the most common construction materials for the pavement of roads. As a multi-phase composite mixture with randomly distributed aggregates inside the mastic part, the mechanical properties of such materials can be influenced by different factors. Cracking and induced fracture is among the common degradation and failure modes in these construction mixtures that often takes place in cold regions. In this research, the effects of some influencing parameters including temperature, air void percentage and loading rate are investigated experimentally on the fracture toughness (K_Ic) and work of fracture (W_Ic) of hot mix asphalt material. Edge notched semi-circular bend (SCB) specimen was employed to conduct mode I fracture experiments. The thickness of SCB samples were considered as variable and the HMA mixtures were tested with two SCB thicknesses of 30 and 60 mm. The experimental results showed that both fracture toughness and fracture work are increased by increasing the thickness. However, the effect of thickness on the fracture work was much more significant than the K_Ic value. Also, the fracture and cracking resistance parameters were increased by decreasing the temperature and air void content. Both K_Ic and W_Ic values were also increased by increasing the loading rate in the investigated range of 1 to 8 mm/min. The most influencing parameters on the change of fracture resistance parameters were the temperature, loading rate, air void content and thickness, respectively.