Recently, there have been a growing number of articles focusing on the benefits of adopting e-SCM systems and the value of such systems in supply chain performance. However, less academic research was devoted to understanding factors affecting the adoption intention of such systems. This study uses the technology, organization, and environment (TOE) framework to examine factors that affect the adoption of e-SCM systems in Jordan, where limited research has been conducted in this country. Through an online survey filled by 251 participants via the LinkedIn website, the study shows that perceived relative advantage, financial resources, employee competency, top management support, competitive pressures, and customer pressure positively impact the adoption intention of e-SCM systems. The findings confirm the association between variables embedded in the TOE framework and the adoption intention of innovative supply chain systems and solutions and support earlier findings. According to the study findings, e-SCM systems providers should focus on the relative advantage these systems offer to increase the likelihood of their adoption.