The goal of this research is to investigate the relationship between human resource management and tourism supply chain management, as well as the effects of human resource and tourism supply chain on customer satisfaction and operation performance. The research was carried out in Vietnam at several tourist destinations. The study found 297 viable samples after screening the sample. A Partial Least Squares (PLS) algorithm was used to process the data. The study's findings revealed a link between human resources and supply chain management in the tourism business. Furthermore, the study discovered that human resource management uncertainty had an impact on organizational performance.