The application of strategic knowledge management requires specific organization structure due to unique and particular characteristics of knowledge. In other words, by passing through industry age toward knowledge age, strategic knowledge management is considered by organizations dramatically and by considering this new competitive edge, universities should prepare an appropriate background for strategic knowledge management (encoding strategy and personalizing strategy). The primary purpose of this research is to find out whether there is a meaningful relationship between organizational structure (recognition, focus and complexity) and strategic knowledge management (codification strategy and personalization strategy) in Azad University, Kermanshah. Organizational structure is considered as independent variables and strategic knowledge management is dependent variables. When it comes to the purpose, present research is an applicable research and based on its nature and method, it is descriptive and survey research. Statistical society consists of university president, vise-president and dean of faculties of Azad University, Kermanshah; during a period of the first half of the year of 2011. Therefore, the sampling method is stratified sampling. Statistical society contains 60 people who are adjusted to 52 sample people by the use of Morgan table. Data collection tool is questionnaire structure questionnaire of Robbins and strategic knowledge management questionnaire of Carolina & ?ngelL. The results of the research show that there is a meaningful relationship between organizational structure and strategic knowledge management in Azad University, Kermanshah, according to codification and personalization strategy. Some suggestions are offered at the end of this research.