The purpose of the current paper is to identify influential aspects of published literature and future research questions to set forth future research agenda based on comprehensive literature review using bibliometric and content analysis. The study analyzed 1225 documents from the international Scopus database using bibliometric analysis and content analysis. VOSviewer software is used for bibliometric analysis. The analysis revealed that most of the information was derived from the Finance Research Letters. Moreover, the United Kingdom is the most cited country, while Tianjin University in China has the highest publications affiliations. Furthermore, the analysis shows that the keyword analysis of cryptocurrency literature had four classes of research streams in cryptocurrency, namely, cryptocurrency, Blockchain, Fintech, and currency, representing the most upcoming trends. The present study makes a significant contribution to the literature by providing a framework for future research. The framework provides opportunities to future researchers to explore the web of relations among some identified research streams as future research agenda.