Bidding strategy is an important part of a negotiation strategy in automated multi-issue negotiations. In order to present good offers, which help maximize the agent’s utility, we need to search the outcome space and find appropriate bids. Bid search can become challenging in large outcome spaces with more than ten thousands of possible bids. The traditional search methods such as exhaustive or binary search are not efficient enough to find the right bids in a large space. This is mostly due to the high number of issues, high number of possible values for each issue, and increased time complexity of usual search methods. In this paper, we investigate the potential of using meta-heuristic methods for optimizing bid search in large outcome spaces. We apply some of the most popular meta-heuristic algorithms for bid search in bidding strategy of baseline negotiating agents and evaluate their impacts on negotiation performance in different negotiation domains. The evaluation results obtained through comprehensive experiments show how meta-heuristic algorithms can help improve bid search capability and consequently negotiation performance of the agents on different performance criteria. In addition, we show which search algorithm is most suitable for improving any particular performance criterion.