Ransomware has evolved into a pervasive and extremely disruptive cybersecurity threat, causing substantial operational and financial damage to individuals and businesses. This article explores the critical domain of Ransomware detection and employs Machine Learning (ML) classifiers, particularly Decision Tree (DT), for Ransomware detection. The article also delves into the usefulness of DT in identifying Ransomware attacks, leveraging the innate ability of DT to recognize complex patterns within datasets. Instead of merely introducing DT as a detection method, we adopt a comprehensive approach, emphasizing the importance of fine-tuning DT hyperparameters. The optimization of these parameters is essential for maximizing the DT capability to identify Ransomware threats accurately. The obfuscated-MalMem2022 dataset, which is well-known for its extensive and challenging Ransomware-related data, was utilized to evaluate the effectiveness of DT in detecting Ransomware. The implementation uses the versatile Python programming language, renowned for its efficiency and adaptability in data analysis and ML tasks. Notably, the DT classifier consistently outperforms other classifiers in Ransomware detection, including K-Nearest Neighbors, Gradient Boosting Tree, Naive Bayes, and Linear Support Vector Classifier. For instance, the DT demonstrated exceptional effectiveness in distinguishing between Ransomware and benign data, as evidenced by its remarkable accuracy of 99.97%.