This study aims to examine the influence of HRM practices (employees’ empowerment, job security, and employees’ participation) and employees’ satisfaction on intention to leave and the mediating role of employees’ satisfaction from the perspective of faculty members in private universities in Kuwait. The survey questionnaire was gathered from 261 faculty members who were working in four private universities in Kuwait. The study used the software SmartPLS (version 3.2.8) to test the study hypotheses. The findings indicate that HRM practices (employees’ empowerment and job security) and employees’ satisfaction had negative effects on intention to leave, and employees’ satisfaction partially mediated the relationship between HRM practices (employees’ empowerment and job security) and intention to leave. Future studies may include other samples as public universities or other sectors in Kuwait such as the education sector or health care sector.