There is no rationalization for a certainty that harder wheels or rails will result in an increase in wear of the opposite side of the wheel/rail interface. This research investigated how the wear of wheel material changes when the hardness of the opposing pair is varied. Three Rail/wheel material matches; normalized UIC50 kg/m and S1002 wheel profile (Rail/wheel material 1), normalized UIC60 kg/m and whole heat treated S1002 wheel profile (Rail/wheel material 2) and rim heat treated UIC60 kg/m and whole heat treated S1002 wheel profile (Rail/wheel material 3) has been investigated using multi-body simulation software (SIMPACK) and MATLAB programming. For validation, as an experimental advantage, the wear depths measured on the wheel tread wear of the end vehicle of LRT for mileage of 50,000 km are compared to the results of numerical simulation performed. As a result, the estimated total tread wear amount after a mileage of 50,000 km is 4% larger than the experimental one. That is indeed a very good result considering that either component of the wheel wear prediction model used is neither adjustment nor calibration. From the three rail/wheel matches, Rail/wheel material 3 found to be the better material match that could resist wear significantly considering material hardness as important criteria for comparison. The study could remark that, despite the fact both wheel and rail material hardness could affect the wear performance in respected positive ways, most significant improvements are attained by improving the rail material hardness ahead of wheel material.