This paper illustrates an innovative manufacturing procedure for producing handcrafted interlocking stabilized compressed earth blocks (ISCEBs). A comparison of the mechanical properties of ISCEBs is conducted to assess the influence of varying components. The ISCEBs are manufactured by employing different block densities with three distinct mixtures (earth, earth and lime, earth and straw) and by using a human-powered machine named Float RAM 1.0 Press. The manual press was conceived for regions with limited access to technology and allows the production of interlocking blocks via two modes of compaction: mono-directional and bi-directional. A production average of approximately 30 blocks/hour corresponding to the work of three people is achieved. Three-point bending tests and uniaxial compression tests are carried out to investigate the ISCEB mechanical behaviour. The improvements obtained by incorporating additives into the subset of ISCEBs made from a pure earth mixture are tested. The aim of this work is to identify, for this specific technology, the relationship between production parameters and the consequent behaviour of different stabilization methods. A correlation is found between the compaction force and the compression strength of ISCEBs. The addition of lime increases strength and causes the blocks to exhibit a brittle behaviour. Moreover, the incorporation of straw fibres improves the tensile strength and ductility without significantly affecting the compression strength of the blocks. Energy-based parameters are obtained for all the tests, allowing the assessment of the ISCEB mechanical and dissipation properties.