[3+2] Cycloadditions of 1-halo-1-nitroethenes with (Z)-C-(3,4,5-trimethoxyphenyl)-N-methyl-nitrone as regio- and stereocontrolled source of novel bioactive compounds: preliminary studies
, Online first: January 2015
Radomir Jasiński, Ewa Dresler, Maria Mikulska and Daniel Polewski PDF (230 K)
Abstract: Preliminary experiments shows, that [3+2] cycloadditions reactions proceeds with full regioselectivity and high stereoselectivity. In consequence, 3,4-trans-2-methyl-3-(3,4,5-trimethoxyphenyl)-4-halo-4-nitroisoxazolidines are forming as predominantly (or sole) products. Additionally, prognosis for the synthesized compounds to be potential ingredients of drugs is good.
Keywords: Cycloaddition, Nitroalkenes, Nitrones, Reactivity, Regioselectivity
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