Volume 7 Number 2 Pages 35-72 | |
Open Access Article | |
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Ultrasound assisted synthesis of 1-amino-3-ferrocenyl-3-oxoprop-1-enes
, Pages: 35-44 Jai N. Vishwakarma, Shilpika Khanikar, Utpalparna Kalita, Shunan Kaping and Madhushree Ray PDF (230 K) |
Abstract: A clean and efficient, mediated in water and assisted by ultrasound method for the synthesis of a series of N-substituted 1-amino-3-ferrocenyl-3-oxoprop-1-enes starting from acetyl ferrocene was developed. Our approach offers shortening of the reaction time under the mild reaction conditions and easy work up procedure. DOI: 10.5267/j.ccl.2018.3.001 Keywords: Enaminones, Michael addition, Nucleophilic substitution, Crystal structure | |
Open Access Article | |
2. |
Spectrophotometric assay of pioglitazone hydrochloride using permanganate in acidic and basic media
, Pages: 45-56 Kanakapura Basavaiah and Nagaraju Rajendraprasad PDF (230 K) |
Abstract: Pioglitazone hydrochloride (PGH) is an oral anti-hyperglycemic agent used in the treatment of type-2 diabetes mellitus. Potassium permanganate was found to oxidize PGH both in acidic and basic conditions, based on which two simple and sensitive methods were developed for its determination in bulk sample and tablets, and validated. In the first method (indirect method), PGH was reacted with a measured excess of standard permanganate in H2SO4 medium, and the residual oxidant was determined by measuring its absorbance at 550 nm. The second method (Direct method) entails treating PGH with permanganate in NaOH medium, followed by the measurement of the resulting bluish-green manganite at 610 nm. Experimental variables affecting the reactions were studied and optimized. Under optimum conditions, linear relationships with good correlation coefficients were found between absorbance and concentration in the ranges, 1.25 – 25 µg mL-1 (Indirect method) and 1-12 µg mL-1 (Direct method) with respective molar absorptivity values of 1.10 × 104 and 2.77 × 104 l mol-1 cm-1. The limits of detection (LOD) and quantification (LOQ) were 0.36 and 1.08 (Indirect method) and 0.23 and 0.69 µg mL-1 (Direct method). Intra-day and inter-day precisions were satisfactory, with %RSD values of ≤2.11, and the respective accuracies were excellent with %RE values of ≤2. The methods were also validated for robustness, ruggedness and selectivity. The methods were applied to the determination of PGH in its tablets with good accuracy and precision, and no interference from the tablet additives was encountered. The results were also compared with those obtained by a reference method. DOI: 10.5267/j.ccl.2018.3.002 Keywords: Pioglitazone, Determination, Permanganate, Spectrophotometry, Pharmaceuticals ► Show Figures
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Open Access Article | |
3. |
NaCl: a facile, environmentally benign catalyst for the synthesis of pyrazole 4-carbonitrile in aqueous media
, Pages: 57-64 Amol Khandebharad, Swapnil Sarda, Mahesh Soni, Charansingh Gill, Pravin Kulkarni Brijmohan Agrawal PDF (230 K) |
Abstract: An ecofriendly methods for the synthesis of medicinally important class of heterocyclic scaffold, pyrazole 4-carbonitrile derivatives by one pot three component reaction of malononitrile, phenyl hydrazine and aromatic aldehyde has been achieved at room temperature. Greener protocols of reaction are followed by using sodium chloride to accelerate the reaction in aqueous media. Present methodology is a condition based divergence on synthesis of pyrazole by using simple salts, which offers several advantages like use of aqueous media and high yield of product along with short reaction time, simple work up procedure, no waste or by products, avoid the use of heavy metals or nanoparticles are the fascinating characteristics of reaction. DOI: 10.5267/j.ccl.2018.3.003 Keywords: Aromatic aldehyde, Malononitrile, Phenyl hydrazine, Pyrazole 4-carbonitrile, Sodium chloride ► Show Figures
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Open Access Article | |
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Synthesis of metal nanoparticles using Heliconia rostrata leaf extract and their antiproliferative and apoptotic property
, Pages:65-72 Lingappa Mallesha, Guruswamy Vinay and Nanjappagowda Dharmappa Rekha PDF (230 K) |
Abstract: The silver and gold nanoparticles were biosynthesized using leaves of a pharmacologically important plant Heliconia rostrata. A rapid, eco-friendly, cost-effective and one-step process of synthesis has been achieved, thus produced nanoparticles were characterized by UV–visible, FT-IR, XRD and TEM spectral studies. Further, newly synthesized nanoparticles were used to study the induction of apoptotic activity on EAT cells. These two types of nanoparticles showed antiproliferative and apoptotic property in mice model. The outcome of this study could be useful for the development of value added products from indigenous medicinal plants, which has biomedical applications. DOI: 10.5267/j.ccl.2018.4.001 Keywords: Heliconia rostrate, Nanoparticles, Anti-proliferative activity ► Show Figures
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