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Lithiation of 2-bromo-4-(1,3-dioxolan-2-yl)-1,3-thiazole
, Pages: 1-8 Vitaliy O. Sinenko, Sergiy R. Slivchuk and Volodymyr S. Brovarets PDF (230 K) |
Abstract: The reaction of lithiation of 2-bromo-4-(1,3-dioxolan-2-yl)-1,3-thiazole with in position 5 of the thiazole ring and double lithiation with t-butyllithium (t-BuLi) in positions 2 and 5 lithium diisopropylamide (LDA) are investigated. When lithiated and dilithiated thiazoles were treated with different electrophiles, a number of trifunctional 1,3-thiazoles were obtained with high yields. DOI: 10.5267/j.ccl.2018.1.002 Keywords: 1,3-thiazole, 2-bromo-4-(1,3-dioxolan-2-yl)-1,3-thiazole, Lithiation, Lithium diisopropylamide, T-butyllithium | |
Open Access Article | |
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Modifications of total synthesis of mycophenolic acid
, Pages: 9-16 Grzegorz Cholewinski, Magdalena Malachowska–Ugarte, Agnieszka Siebert, Michał Prejs and Krystyna Dzierzbicka PDF (230 K) |
Abstract: The total synthesis of mycophenolic acid (MPA), a potent immunosuppressant, was modified. The obtained mycophenolic acid was suitable for further preparation of new prospective immunosuppressants with improved therapeutic properties. DOI: 10.5267/j.ccl.2018.1.001 Keywords: Mycophenolic acid, Immunosuppressants, Claisen rearrangement, Oxidation, Total synthesis ► Show Figures
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Open Access Article | |
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New strategy for chemically attachment of Amide group on Multi-walled Carbon Nanotubes surfaces: synthesis, characterization and study of DC electrical conductivity
, Pages: 17-26 Abeer Obeid, Omar Al-Shuja’a, Yousuf El-Shekeil, Salem Aqeel, Mohd Sapuan Salit and Zinab Al-Washali PDF (230 K) |
Abstract: A new method of amidation of Carboxy Multi Walled Carbon Nanotubes (MWCNT-COOH) with diamine monomer such as ethylene diamine (EDA) and O-Phenylenediamine (OPDA) was applied by using a solution blending technique. The structure and properties of these composites have been investigated by FTIR, SEM, TEM, XRD, UV, DSC and TGA. The formation of Poly [MWCNT/ Amide] composites was confirmed and the DC electrical conductivity of poly-composites was in the range 4.5×10-6-5.3×10-6 S/cm due to the interaction between the nanotubes. DOI: 10.5267/j.ccl.2017.11.001 Keywords: MWCNT-COOH, Polymer nanocomposites, Functionalization, Solution blending, Polyamide ► Show Figures
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A DFT computational study on the [3+2] cycloaddition between parent thionitrone and nitroethene
, Pages: 27-34 Karolina Kula and Agnieszka Łapczuk-Krygier PDF (230 K) |
Abstract: A molecular mechanism of the [3+2] cycloaddition has been explored using various DFT theoretical levels. It was found that the reaction proceeds via transition states with different synchronicity, but no intervention of the theoretical possible zwitterionic intermediates. Additionally, regioselectivity of the cycloaddition process has been analysed using vibrational analysis of localised TSs. DOI: 10.5267/j.ccl.2018.02.001 Keywords: Thionitrone, Nitroethene, Nitroisothiazolidine, [3+2] cycloaddition, DFT study ► Show Figures
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