1. |
Synthesis and crystal structure of (E)-3-(2-methyl-1H-indol-3-yl)-1-(4-methylphenyl)propenone
, Pages: 47-50 Jai N. Vishwakarma and Farlando Diengdoh PDF (230 K) |
Abstract: (E)-3-(2-Methyl-1H-indol-3-yl)-1-(4-methylphenyl)propenone has been prepared, and its crystal structure (C19H17NO, Mr = 275.34) has been determined by single-crystal X-ray diffraction analysis. The title compound crystallized in the triclinic system with space group P1 and unit cell parameters: a = 9.4014 (5) Å, b = 9.8347 (4) Å, c = 10.0318 (5) Å, α = 62.821 (3)°, β = 85.539 (3)°, γ = 65.262 (3)° and Z = 2. The final reliability index is 0.053 for the 2807 observed reflections. The title compound is linked through N–H···O hydrogen bonds. DOI: 10.5267/j.ccl.2016.1.003 Keywords: Enaminone Hydrogen bonds Crystal Structure Chalcone Indole |
|
2. |
The immobilized NaHSO4·H2O on activated charcoal: a highly efficient promoter system for N-formylation of amines with ethyl formate
, Pages: 51-58 Behzad Zeynizadeh and Mohammad Abdollahi PDF (230 K) |
Abstract: The immobilized NaHSO4·H2O on activated charcoal was used as a highly efficient promoter system for facile N-formylation of amines with ethyl formate. All reactions were carried out in refluxing ethyl formate (54 ºC) under mild conditions within 10-100 min to afford the product formamides in high to excellent yields (80-94%). DOI: 10.5267/j.ccl.2016.1.002 Keywords: Amines, Activated charcoal, Ethyl formate, Formylation, NaHSO4·H2O |
|
3. |
Preparation of E-1,3-diaminoethenyl functional groups by the reaction of enol tosylate of alpha-formylglycine with primary and secondary amines
, Pages: 59-70 Sitaram Bhavaraju PDF (230 K) |
Abstract: The E-1,3-diaminoethenyl functional group is a potentially useful synthon. A number of examples of E-1,3-diaminoethenyl functional groups were prepared in good yield starting from an E-enol tosylate of a serine based diketopiperazine and 1°- or 2° amine nucleophiles. The reaction proceeds via a stereoselective nucleophilic substitution pathway. DOI: 10.5267/j.ccl.2016.1.001 Keywords: Dehydroamino acids, E-1,3-diaminoethenyl group, Alpha-formylglycine (α-FGly), Enol tosylate, Nucleophilic substitution |
|
4. |
Schiff bases of 4-(methylthio)benzaldehydes: Synthesis,characterization, antibacterial, antioxidant and cytotoxicity Studies
, Pages: 71-82 Chimatahalli S. Karthik, Lingappa Mallesha, Shivashankarappa Nagashree Puttaswamappa Mallu, Vasanth Patil and Sathish Kumar PDF (230 K) |
Abstract: A series of new Schiff bases of 4-(methylthio)benzaldehyde derivatives 3(a-i) were synthesized by the reaction of 4-(methylthio)benzaldehyde with various amines 2(a-i). Newly synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, Mass and 1H NMR spectral studies. All compounds were evaluated for their in vitro antibacterial activity against clinically isolated strains i.e., E. Coli, P. Fluorescence, M. Luteus and B. Subtilis. These compounds were screened for their antioxidant activity by 2,2-diphenyl-1-picryl-hydrazyl (DPPH•) and ferrous ion chelating assay (Fe2+) methods. The cytotoxicity assay was performed by tryphan blue dye exclusion method. Compounds 3g, 3h and 3i exhibited good antibacterial activity when compared with other compounds in the series against tested pathogenic bacterial strains. All the compounds showed antioxidant activity, where compound 3b was the best radical scavenger and Fe2+ ion scavenger. These findings showed that the Schiff bases of 4-(methylthio)benzaldehyde derivatives possess antioxidant activity with different mechanism of actions towards the different free radicals tested. Among these derivatives, 3b and 3h had the strongest activity against human peripheral lymphocytes. DOI: 10.5267/j.ccl.2015.12.002 Keywords: 4-(Methylthio)benzaldehyde, Cytotoxicity, Antibacterial, Antioxidant |
|
5. |
Simple and rapid synthesis of some nucleoside derivatives: structural and spectral characterization
, Pages: 83-92 Shagir A. Chowdhury, Mohammad M. R. Bhuiyan, Yasuhiro Ozeki and Sarkar M. A. Kawsar PDF (230 K) |
Abstract: In our present investigation a new series of nucleoside derivatives (2-13) were synthesized from uridine (1) via only two step reactions by direct acylation method. Firstly, uridine (1) was treated with 4-t-butylbenzoyl chloride in pyridine at -5ºC and afforded the 5´-O-(4-t-butylbenzoyl)uridine derivative (2) in an excellent yield. In order to obtain newer products, the 5´-O-uridine derivative was further transformed to a series of 2´,3´-di-O-acyl derivatives (2-13) containing a wide variety of functionalities in a single molecular framework. The yields of the compounds were more than 80%. The synthesized titled compounds were characterized by their physical properties, FTIR (Fourier transform infrared spectroscopy), 1H-NMR (Nuclear magnetic resonance) spectroscopy and elemental analysis. DOI: 10.5267/j.ccl.2015.12.001 Keywords: Uridine, Acylation, Physicochemical, Compounds, Spectroscopy |
|
® 2016 GrowingScience.Com