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An efficient and green procedure for the synthesis of highly substituted polyhydronaphthalene derivatives via a one-pot, multi-component reaction in aqueous media
, Pages: 85-92 Adeleh Moshtaghi Zonouz, Issa Eskandari and Behrouz Notash PDF (230 K) |
Abstract: A simple, efficient and green one-pot, four-component synthesis of highly substituted polyhydronaphthalenes in aqueous media is described. The method has such advantages as short reaction times, high yields, mild reaction conditions, operational simplicity and environmentally benign. DOI: 10.5267/j.ccl.2015.4.004 Keywords: Polyhydronaphthalene, 2,6-dicyanoanilines, Multi-component reaction Aqueous media |
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Boron sulfonic acid (BSA) catalyzed selective synthesis of aryl-bis(2-hydroxynaphth-1-yl)methanes and 14-alkyl- and 14-aryl-14H-dibenzoxanthenes under solvent-free condition
, Pages: 93-100 P. Dutta and R. Borah PDF (230 K) |
Abstract: This study investigated the selective synthesis of aryl-bis(2-hydroxy-1-naphthyl)methane for the first time under microwave irradiation in solvent-free medium within 5 min using 10 mol % of B(HSO4)3 (BSA) as reusable solid acid catalyst. The same reaction could also be conducted at 90-100 °C in neat for the formation of alkyl or aryl 14H-dibenzoxanthenes in presence of BSA catalyst with excellent yields. DOI: 10.5267/j.ccl.2015.4.003 Keywords: Aryl-bis(2-hydroxy-1-naphthyl)methanes, Dibenzoxanthenes, B(HSO4)3, Reusable solid acid, Neat condition |
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Determination of lipophilicity of some new 1,2,4-triazole derivatives by RP-HPLC and RP-TLC and calculated methods
, Pages: 101-110 Anna M. Hawrył, Ryszard S. Świeboda, Mateusz S. Gawroński, Magdalena A. Wójciak-Kosior, Łukasz P. Popiołek and Ryszard B. Kocjan PDF (230 K) |
Abstract: Experimental and computational approaches were used to estimate the lipophilicity of novel 1,2,4-triazole derivatives. These derivatives have been subjected to this research, because they exhibit antimicrobial activity. The chromatographic analysis of RP-HPLC and RP-TLC was carried out using methanol-water or acetonitrile-water as mobile phase. The linear relationships between logk (or RM) values and the concentration of organic modifier were obtained. The lipophilicity was expressed as chromatographically derived descriptors: logkW, S, ϕ0 and scores logk and R_Mcorresponding to the first principal component. The experimental lipophilicity data have been compared with the computer calculated lipophilicity parameters (milogP, clogP, ALOGPs, AClogP, AlogP, MLOGP, KOWWIN, XLOGP2, XLOGP3, logPChS) of the same molecules. The matrices were created with logkW or RM0and logP and they have been the subject of PCA analysis. DOI: 10.5267/j.ccl.2015.4.002 Keywords: lipophilicity, 1,2,4-triazole derivatives Computed logP, RP-HPLC, RP-TLC, PCA |
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Activated charcoal: a highly efficient promoter for selective oxidation of alcohols to aldehydes and ketones by K2S2O8 at solvent-free conditions
, Pages: 111-118 Akbar Safari and Behzad Zeynizadeh PDF (230 K) |
Abstract: Selective oxidation of primary and secondary alcohols to the corresponding aldehydes and ketones was achieved efficiently using K2S2O8/activated charcoal system. All reactions were carried out at solventfree conditions (40-45 ºC) within 15-60 min to give the products in high to excellent yields. DOI: 10.5267/j.ccl.2015.4.001 Keywords: Activated charcoal, Aldehydes, Ketones, K2S2O8, Oxidation |
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An efficient method for the synthesis of substituted N-aryl lactams
, Pages: 119-126 Devdutt Chaturvedi, Amit K. Chaturvedi, Pragyandip P. Dash and Nisha Mishra PDF (230 K) |
Abstract: A quick, efficient, and one-pot method for the synthesis of substituted N-aryl lactams through the reaction of various kinds of corresponding substituted arenes with a variety of ω-azido alkanoic acids using trifluoromethanesulfonic acid (triflic acid) at room temperature, by in-situ involvement of Friedel-Crafts reaction followed by intramolecular Schmidt rearrangement was developed, and afforded good to excellent yields. DOI: 10.5267/j.ccl.2015.3.005 Keywords: Arenes, ω-Azido alkanoic acid, Triflic acid, Substituted N-aryl lactams |
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An Infraspec VFA-IR spectrometer analysis of Trans-fat content in glazed donuts purchased from supermarkets, convenience stores and bakeries
, Pages: 127-132 Sharron Jenkins and Patty Campbell PDF (230 K) |
Abstract: Most packaged food products must contain trans-fat labelling; however unpackaged snacks such as cookies, donuts, and muffins at supermarkets, gas station convenience stores, and bakeries often do not have or require nutrition fact labels. Hence, consumers are not aware of the trans-fat content in unpackaged food products. It is well-known within the health and scientific community that diets high in trans-fat can lead to a host of health problems, namely coronary heart disease (CHD). The purpose of this study is to conduct a preliminary study of the trans-fat content in unpackaged baked goods, particularly unpackaged glazed donuts. To accomplish our objective, we determined the % trans-fat in oil extracted from glazed donuts obtained from several supermarkets, gas stations and bakeries across Northwest, Indiana. Variable Filter Array (VFA) IR spectroscopy was used to assess the trans-fat content of oil extracted from food samples. In this paper, we present our preliminary findings. DOI: 10.5267/j.ccl.2015.3.004 Keywords: Trans-fat, Baked goods, Donuts, Spectroscopy, ATR-FTIR |
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