The study of cycloaddition reactions between cyclopenta-1,3-diene and benzyl-acrylate, as well as benzyl-2-fluoroacrylate with and without the catalyst (TiCl4), was conducted using MEDT. The results of the energy profiles suggest that these reactions are stereoselective, meaning that they favor the formation of certain stereoisomers over others. Furthermore, the addition of TiCl4 as a catalyst appears to enhance the selectivity of these reactions, which is in line with experimental observations. Additionally, a docking study was carried out to predict the effect of stereochemistry and the presence of specific atoms, such as fluorine, on their ability to bind to viral proteins responsible for SARS-Covid-19 and HIV. Moreover, the notable affinity of Ligand 4 for HIV renders it a pivotal contender for extended research, possibly paving the way for enhanced antiretroviral drugs. Similarly, the encouraging affinity demonstrated by Ligand 1 towards the Covid-19 protein highlights its promise for Covid-19 drug development.

We have synthesized all drugs using previously identified active pharmacophores through molecular hybridization. This paper explains a simple method for making N-((2-(piperazine-1-yl)-2,3-dihydro-1H-benzo[d][1,2,3]triazol-1-yl)methyl)aniline analogs 5(A–L) through steps. We used mass spectrometry, ¹H NMR, and ¹³C NMR to do a spectrum analysis to confirm the structure of the synthesized end products. We evaluated all synthesized compounds for their in vitro antimicrobial, antimalarial, and antitubercular activities. We have also examined the research on structure-activity relationships (SAR). Target chemicals demonstrate significant effectiveness against bacteria, fungal diseases, and malaria.

Benzotriazole, commonly referred to as BTAH, has garnered significant interest across several scientific disciplines due to its outstanding characteristics and wide-ranging applications. This document provides a concise overview of benzotriazole and its use in challenging corrosion scenarios. Furthermore, we emphasize the versatility of this molecule and the extensive research commitment associated with it. This thorough analysis examines the synthesis of benzotriazoles and their derivatives in-depth and encapsulates the numerous methods involved. Additionally, we conducted a thorough analysis of toxicity studies and the pertinent implications of benzotriazoles on human health, marine life, and the ecosystem. Our purpose is to provide readers with a thorough understanding of the potential dangers of this chemical by undertaking an extensive examination of associated risks and bad effects. During this review, we emphasize significant research discoveries and trends, offering useful insights into the current status of benzotriazole research and its future potential. The development of such research advances from 2010 to 2024.

Heterocyclic molecules are found in many parts of living things, so they are being used more and more in medicinal chemistry. Benzimidazoles, which are naturally occurring compounds, exhibit a diverse array of pharmaceutical properties that have been extensively documented. Benzimidazole derivatives serve as valuable intermediates or subunits in the synthesis of pharmaceutical or biologically significant compounds. Substituted benzimidazole derivatives have been utilized in various therapeutic domains, encompassing but not limited to antiulcer, anticancer agents, and anthelmintic species. This study provides a systematic and comprehensive overview of the latest advancements in benzimidazole-based compounds within the field of synthetic organic chemistry.

This review presents 1,3,4-oxadiazole which has considerable importance in the fields of pharmacy, medicine, corrosion and coordinate chemistry. 1,3,4-oxadiazole plays a vital role and is a simple substance for many pharmacokinetic compounds such as antifungal drugs, antibacterial drugs, most cancer tumors and anti-inflammatory drugs. This study describes many methods for the synthesis of 1,3,4-oxadiazole.

In the present work, we report an efficient synthesis and antioxidant activity evaluation of some 4-arylimino-thiazolidin-2-ones. The structures of target substances were confirmed through ¹H and ¹³C NMR spectroscopy, mass spectrometry and elemental analysis. The antioxidant activity of the synthesized compounds was measured in vitro by the method of scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. Notably, antioxidant activity was identified for the first time among 4-arylimino-thiazolidin-2-ones.

Methodology is reported for the synthesis of a six-membered heterocyclic ring involving cyclocondensation reaction through sulfur-sulfur bond formation. This method of synthesis allows for developing a new class of dithiadiazines. A series of bis-[6-tetra-O-acetyl-β-D-glucopyranosylimino-1,2,4-triazolo[3,4-b]-1,2,4,5-dithiadiazin-4-yl] alkanes have been synthesized by using a reagent, tetra-O-acetyl-β-D-glucopyranosylimino chloromethane sulfenyl chloride and bis-(4-amino-5-mercapto-1,2,4-triazol-3-yl) alkanes. These newly formulated N-glycosylated molecules could serve as a potential biological entity.

The past decade has witnessed significant progress in synthesizing structurally diverse and biologically relevant pyrano[2,3-c]pyrazole derivatives through the integration of green methodologies. A straightforward and environmentally friendly one-step method has been developed to synthesize divergent pyranopyrazoles in good yields with the aid of zinc acetate as a Lewis acid catalyst in toluene as solvent under reflux conditions.

Through the implementation of a simple, environment friendly one-pot multicomponent reaction with 1 mmol of methyl acetoacetate, 2 mmol of different substituted aromatic aldehydes, and 2 mmol of different substituted aromatic anilines in the presence of triethylammonium hydrogen sulfate [Et3NH][HSO4] bronsted acid as an ionic liquid catalyst and Ethanol: water as a green solvent at 60°C temperature. We have developed an affordable and dynamic procedure for the synthesis of novel, medicinally essential tetrahydropyridine derivatives. One-pot multicomponent synthesis is an energetic topic in heterocyclic chemistry due to its vital advantages of simple reaction process, high atom economy, low cost, less amount of waste generation, and simple workup procedures, which make this process economically productive for industrial applications. The final compounds were confirmed via FTIR, ¹H-NMR, and ¹³C-NMR spectroscopy and were in contrast with their reported methods.

This research is aimed at analyzing perception and identifying determinants of the decision to convert to organic mango farming in Mekong Delta (MD) Vietnam. The research was conducted by using a direct survey data set from 109 household heads in this region collected by stratified random sampling method. The research method used was descriptive statistics and the binary Logit model. The research results revealed some interesting points. In the total observations gathered, only about half of households decided to convert, mainly due to local implementation and awareness of safety for consumers and environmental protection. Still, the most important reason for farmers to convert was to get a higher selling price. The binary Logit model analyzing the determinants found that the older the farmer, the more difficult it is to decide to convert. At the same time, training and enhancing awareness about organic farming will increase the probability of conversion decisions. Based on the research results, several relevant solutions on investment, production linkage, and propaganda to raise people's awareness were recommended, thereby increasing the probability of deciding to convert.