The current work involves the synthesis of amalgamated heterocyclic scaffolds embracing pyrazolone and triazole nuclei. The suggested methodology leads to streaming in the targeted synthesis in a multicomponent reaction manner resulting in 91% yield of the structural motifs. This strategy makes use of the click reaction mechanism of copper-catalyzed azide-alkyne (CuAAC) cycloaddition. The structures of all the synthesized compounds were ascertained considering spectro-analytical data from 1H NMR, ¹³C NMR, and FTIR and Mass studies. Subsequently, molecular docking studies were performed taking into account the P. gingivalis as the heme binding targeted protein.

The mechanism and regioselectivity of 1,3-dipolar reaction of 2-azido-N-(4-diazenylphenyl) acetamide and an alkyne have been studied in gas phase and in DMSO using the B3LYP-GD3 functional and 6-31G(d,p) basis set. The reaction followed a one-step mechanism with asynchronous TSs. The calculated global reactivity indices calculated revealed, among other things, the nucleophile character of the 2-azido-N-(4-diazenylphenyl)acetamide and the electrophile character of the alkyne (4-bromo-2-chloro-1-ethynylbenzene), in addition to an electron transfer from the 4-bromo-2-chloro-1-ethynylbenzene towards the 2-azido-N-(4-diazenylphenyl) acetamide. The calculated local reactivity indices predicted the formation of the 1,4-triazole, with the most nucleophilic nitrogen and the most electrophilic carbon favoring its formation. However, analysis of the activation energies and thermochemistry parameters showed that the 1,5 triazole is energetically favorable and more stable under thermodynamic control. Bond order analysis coupled with bond formation evolution and the solvent effect was further investigated to support and highlight the asynchronicity in bond formation and the regioselectivity of the reaction, respectively.

Artemisia herba-alba is a perennial herbaceous plant belonging to the Asteraceae family. It is used in folk medicine to treat many nervous and digestive disorders, as well as diabetes. It possesses antioxidant, antifungal and anti-inflammatory properties. The chemical composition of the organic extracts obtained from the leaves of the Syrian Artemisia herba-alba plant was analysed using a Soxhlet extraction device and three solvents with varying degrees of polarity (petroleum ether, chloroform and ethyl acetate). The chemical constituents of the three extracts were determined using GC/MS technology. In the petroleum ether extract (Ah1), 38 compounds were identified, while the chloroform extract (Ah2) contained 39 compounds, and the ethyl acetate extract (Ah3) contained 45 compounds. The most significant compounds in the Ah1 extract were longiverbenone (23.9%), heneicosane (18.2%), 3,3,6-trimethyl-1,5-heptadien-4-one (16.5%), caryophyllene oxide (5.8%), and octacosane (4.6%). In the Ah2 extract, the main constituents were dioctyl hexanedioate (13.2%), (Z,Z) 9,12-octadecadienoyl chloride (7.3%), and (-)-spathulenol (7.1%). The primary compounds in the Ah3 extract were pentanoic acid (9.5%), geranyl isovalerate (9.3%), 2-butyl-1-octanol (7.5%), and 1-heptadecene (6.4%).

While the number of AIDS-related deaths continues to rise, efforts have been made to transform the disease into a manageable chronic condition. HIV protease inhibitors have become central to combination therapy. As a result, these inhibitors have become a major focus of anti-HIV drug development. This research takes a data-driven approach to drug development through the use of quantitative structure-activity relationship (QSAR) analysis. A dataset of 450 anti-HIV drugs was used to construct and validate models. Using extensive validation methods and various machine learning algorithms, the results clearly showed that the "ET" regression outperformed the other models (“XGB”, “LGBM”, “DT”, “RF”, “GB”, “Bag”, and “HGB”) in terms of goodness of fit, predictivity, generalizability, and model robustness. Promising compounds were subjected to molecular docking and molecular dynamics simulation, resulting in drugs with favourable pharmacokinetic and pharmacodynamic properties that consistently interact with the therapeutic target.

This short communication reports about new 5-amino-4-(1H-tetrazol-5-yl)-1,3-oxazoles which were synthesized by [3+2] cycloaddition of 2-R-5-amino-1,3-oxazole-4-carbonitriles and trimethylsilyl azide with dibutyltin oxide present. The reaction conditions provided high yields of the products, and were tolerant to some active functional fragments in the oxazole substituents (amino, amido, and hydroxy group). In the case of 2-((4-cyano-2-phenyloxazol-5-yl)amino)-N-methylacetamide the by-product (N-((1-(2-(methylamino)-2-oxoethyl)-1H-tetrazol-5-yl)(1H-tetrazol-5-yl)methyl)-benzamide) was formed together with the expected tetrazolyloxazole.

Credit risk affects the work and reputation of banks. Islamic banks' heavy reliance on debt financing has led to increased interest in credit risk and its management. This paper aimed to identify the bank-specific factors affecting credit risk in Islamic banks, expressed as Non-Performing Finance NPF in the Middle East for the period 2011-2022. The study was based on a panel data analysis of 30 Islamic banks. The findings of study show a significant negative impact of Return On Assets ROA, Capital Adequacy Ratio CAR and size Z on the credit risk. The findings show a significant positive impact of Finance Loss Provision FLP on the credit risk. The findings also show no impact of Finance Expansion FEX, Finance to Deposit Ratio FDR and Capital Ratio CPR on the credit risk. The study showed that increasing the provision for financing losses and capital adequacy helps banks to reduce the impact of credit risks. The study recommends applying cautious lending policies and carefully selecting clients.

This research aims to investigate the upcoming challenges of green innovation and sustainability in the hospitality and tourism sectors of Saudi Arabia and the mediating role of National Vision 2030 in fostering industry growth. A quantitative design was used, and a close-ended questionnaire was used to collect data from 499 respondents in the hospitality and tourism sectors of Saudi Arabia. The analysis was performed using SmartPLS and structural equation modeling (SEM). The findings indicate several upcoming challenges, such as renewable energy consumption, energy efficiency, and the changing preferences of consumers. However, these challenges can be dealt with adequate government policies and the mediating role of the Saudi Arabia 2030 vision to achieve sustainability in the hospitality and tourism sectors. These findings have theoretical and practical implications, which are discussed in the end. The scope of the findings is constrained to the geographic context of Saudi Arabia, inviting future investigations in a broader international context.

Retail food businesses are important contributors to the economic stability of nations, contributing to the economy in different ways, including providing jobs in the supply chain pipeline. Global events like the pandemic arising from the spread of COVID-19 threatened the aptitude of retail food outlets to operate due to the restrictions put in place to mitigate the spread of the virus. The objective of this research is to investigate the determinants that impact the longevity of organizations in the food retail industry and construct a survival model that accounts for these characteristics considering the COVID-19 pandemic, and examining the roles of variables such as organizational survival, external general environment, corporate governance policy, transformational change management, economic condition, and marketing innovation. The study utilized quantitative methodology, employing a survey questionnaire to gather data from a sample of 360 entrepreneurs. Subsequently, the data was analyzed using statistical analysis and the Structural Equation Model (SEM). The research findings reveal that the external general environment, transformational change management, economic conditions, corporate governance policies, and marketing innovation have statistically significant positive impacts on organizational survival. Consequently, food retail businesses must adapt within the COVID-19 context, under evolving external conditions, to strategize for enhanced competitive capabilities. This includes managing change and economic conditions for survival in a COVID-19 pandemic characterized by rapid economic shifts, human behavioral changes, and adaptive governance policies that align with situations. These findings can be applied to organizational structures, addressing weaknesses and further enhancing organizational strengths to create innovative marketing approaches that align appropriately with current circumstances for organizational survival. An important limitation of the study is that data were collected from only 360 food retailers in Thailand, representing a partial population of the food retail business in Thailand, hence limiting the generalizability of the results beyond the context of the study and other countries.

Financial performance is an evaluation of a company's assets, liabilities, equity, expenses, revenues, and profitability. This evaluation provides an overview of the company's overall financial health during a certain period. Resource Based Theory states several factors that can affect financial performance, namely intellectual capital and competitive advantage. This research was conducted with a quantitative approach. The observed population of this research is all BPRs in Bali Province which are still operating in 2017 - 2021. Determination of the sample in this study using the census method or saturated sample so that the sample used in this study was 133 BPRs in Bali Province. The analysis technique used in this research is path analysis with Eviews version 9.0 software. The test results show that intellectual capital has no effect on financial performance, intellectual capital has a positive effect on competitive advantage, competitive advantage has a positive effect on financial performance and competitive advantage is able to mediate the effect of intellectual capital on financial performance. The results of this study are expected to contribute to various interested parties, namely the development of Resource Based Theory as a theoretical benefit and BPR management, government, OJK, society and the banking industry as practical beneficiaries.

The research aims to investigate how strategic entrepreneurship through innovative effectiveness is used to create value within firms. Using structural equation modeling, data from 55 private hospitals in Jordan were gathered. For this research, 230 directors, managers, and department heads were enlisted. An entrepreneurial mindset was found to have a significant and positive correlation with innovative effectiveness while having a business alignment also had a positive and significant correlation with innovative effectiveness. However, innovative effectiveness had a positive but insignificant correlation with the creation of firm value. The research concluded that strategic entrepreneurship had a positive effect on the creation of firm value.