Entrepreneurship is vital for enhancing an organization position among its rivals and may establish new opportunities. The positive effects of entrepreneurship are realized, however, if the business environment is receptive to innovation; especially the internal environment within its leadership, it can act as a motivator for it. This study aimed to identify the impact of entrepreneurship on organizational excellence through the mediating role of visionary leadership, where the study population was the managers at different levels in the Jordan commercial bank. A random sample was used to collect data from (54) branch distributed between Jordan and West Bank, where the sample consisted of (183) distributed questionnaires, while the valid questionnaires for statistical analysis were (154), which is reflected a responding rate of (84.15%) of distributed questionnaires. Structural Equation Modeling (SEM) was applied as a statistical method to attain the study objectives and testing its hypotheses. The study results indicated that entrepreneurship with its dimensions (innovativeness, pro-activeness, risk-taking, and aggressive competition) had a significant impact on both visionary leadership and organizational excellence, also visionary leadership had a significant impact on organizational excellence, while the mediating test referred that the visionary leadership played a partial mediating role between entrepreneurship and organizational excellence. Consequently, the study concluded that external and internal environments could act as a motivator for entrepreneurship and consequently for achieving organizational excellence through having visionary leadership and flexible structures and policies.