The purpose of the present study was to examine the effects of cultural intelligence (CQ) and emotional intelligence (EI) on a tour leader’s adjustment in a different cultural environment. Data were collected from 330 outgoing tour leaders in Tehran, Iran. The construct validity was confirmed by using confirmatory factor analysis. The data were analyzed using correlation analysis and path analysis to test the effect of CQ on cross-cultural adjustment, and the moderating effect of EI on the relationship between CQ and cross-cultural adjustment. The results showed that CQ had a positive effect on cross-cultural adjustment. In addition, we found that CQ had a positive effect on EI. The findings of the research showed that emotional intelligence in not significantly the mediator variable. Emotional intelligence has a positive and significant effect on cross-cultural adjustment. The findings of this study contribute to the body of knowledge in the ?eld of CQ and cross-cultural research, and it provides practical implications for individuals seeking to improve their cross-cultural effectiveness, enhancing their cultural intelligence and emotional intelligence, specifically in tourism industry.