This study analyzes the effect of organizational empowerment on innovative work behavior (IWB) mediated by knowledge management and teaching creativities. A questionnaire collected the research data. The sample of this research includes 386 teachers selected by accidental sampling. Data analysis uses path analysis supported by descriptive statistics and correlational. The results show that organizational empowerment had a positive and significant effect on IWB, directly and indirectly, mediating by knowledge management and teaching creativity. Thus, the teacher’s IWB can be improved through organizational empowerment, knowledge management, and teaching creativity. A fit research model about the effect of organizational empowerment on IWB mediating by knowledge management and teaching creativity was found. This model can adopt as a reference by researchers and practitioners in developing IWB models in the future and multiple organizations context.