Supply chain resilience has rapidly expanded as a research area due to increased vulnerability to disruptions and uncertainties. Integration and re-engineering are essential components of a resilient supply chain that can improve its performance. Nevertheless, no one has yet investigated the effect of Artificial intelligence (AI) on the relationship between integration and re-engineering. Therefore, this study aims at investigating the roles of supply chain integration and re-engineering on supply chain performance. Similarly, it investigated the moderating role of AI in these relationships. This study develops a theoretical framework based on resource-based view and the social construction of technology theory. Based on a quantitative study of 564 responses collected from supply chain and clinical unit managers in the Qatari public healthcare sector, an empirical analysis was made using the partial least squares (PLS) path modelling technique. Results revealed that supply chain integration and re-engineering positively affect supply chain performance. Most significantly, these relationships are found to be positively moderated by AI. This study confirms the impact of supply chain integration and re-engineering on performance, providing empirical evidence for AI's role in strengthening these relationships.