The organizational performance at Punjab healthcare is crucial and often faces stock-outs of critical medicines and equipment at emergency department of different hospitals, which increased the mortality rate. Therefore, the study determined the effect of disruptive factors and inventory control as a mediator on organizational performance. Quantitative method with survey questionnaires on a 200-sample size through cluster sampling was used. SPSS and AMOS were used to examine Exploratory Factor Analysis, Confirmatory Factor Analysis, and Structural Equation Modeling. The results found full mediation with a significant positive effect between study variables. Further, the study indicated that strict compliance of standardized operating procedures, professionally well-equipped staff, stock availability, and accurate inventories could reduce costs with improved service quality. This study is useful for the public healthcare facilities, ministries managing inventories and body of knowledge. Finally, the backlog inventories at public sector organizations need to be researched in future.