In the case of disruptions in the blood supply chain, rapid reorganization of distribution processes is required to ensure an effective response to emergency situations. This paper considers the problem of redistributing available blood stocks from the institute and hospitals to hospitals affected by a disruption. A mathematical formulation of the problem is developed, with a multi-objective function aiming to: (i) minimize the blood delivery time to the locations of disruption, (ii) minimize violations of predefined safety stock levels at the institute and hospitals, and (iii) minimize the amount of blood taken from hospitals not affected by the disruption. The formulation also introduces constraints that ensure balanced violations of safety stock levels across unaffected facilities. Computational experiments are conducted on test scenarios generated from real case studies from the healthcare system of the Republic of Serbia. Small-sized instances can be solved exactly, providing benchmarks for evaluating a General Variable Neighborhood Search metaheuristic designed for larger problem instances. The results indicate that the proposed metaheuristic produces high-quality solutions within negligible CPU time.

This document addresses the problem of scheduling and routing a specific number of vehicles to visit a set of customers in specific time windows during a planning horizon. The vehicles have a homogeneous limited capacity and have their starting point and return in a warehouse or initial node, in addition, multiple variants of the classic VRP vehicle routing problem are considered, where computational complexity increases with the increase in the number of customers to visit, as a characteris-tic of an NP-hard problem. The solution method used consists of two connected phases, the first phase makes the allocation through a mixed-integer linear programming model, from which the visit program and its frequency in a determined plan-ning horizon are obtained. In the second phase, the customers are grouped through an unsupervised learning algorithm, the routing is carried out through an Ant Colony Optimization metaheuristic that includes local heu-ristics to make sure com-pliance with the restrictive factors. Finally, we test our algorithm by performance measures using instances of the literature and a comparative model, and we prove the effectiveness of the proposed algorithm.

Due to its proactive impact on the serviceability of components in a system, preventive maintenance plays an important role particularly in systems of geographically spread infrastructure such as utilities networks in commercial buildings. What makes such systems differ from the classical schemes is the routing and technicians' travel times. Besides, maintenance in commercial buildings is characterized by its short tasks’ durations and spatial distribution within and between different buildings, a class of problems that has not been suitably investigated. Although it is not trivial to assign particular duties solely to multi-skilled teams under limited time and capacity constraints, the problem becomes more challenging when travel routes, durations and service levels are considered during the execution of the daily maintenance tasks. To address this problem, we propose a Mixed Integer Linear Programming Model that considers the above settings. The model exact solution recommends collaborative choices that include the number of maintenance teams, the selected tasks, routes, tasks schedules, all detailed to days and teams. The model will reduce the cost of labor, replacement parts, penalties on service levels and travel time. The optimization model has been tested using different maintenance scenarios taken from a real maintenance provider in the UAE. Using CPLEX solver, the findings demonstrate an inspiring time utilization, schedules of minimal routing and high service levels using a minimum number of teams. Different travel speeds of diverse assortment of tasks, durations and cost settings have been tested for further sensitivity analysis.

This paper focuses on the problem of scheduling and routing workers in a courier service to deliver packages for a set of geographically distributed customers and, on a specific date and time window. The crew of workers has a limited capacity and a time window that represents their labor length. The problem deals with a combination of multiples variants of the vehicle routing problem as capacity, multiple periods, time windows, due dates and distance as constraints. Since in the courier services the demands could be of hundreds or thousands of packages to be delivered, the problem is computationally unmanageable. We present a three-phase solution approach. In the first phase, a scheduling model determines the visit date for each customer in the planning horizon by considering the release date, due date to visit and travel times. We use an expert system based on the know-how of the courier service, which uses an inference engine that works as a rule interpreter. In the second phase, a clustering model assigns, for each period, customers to workers according to the travel times, maximum load capacity and customer’s time windows. We use a centroid based and sweep algorithms to solve the resulted problem. Finally, in the third phase, a routing model finds the order in which each worker will visit all customers taking into account their time windows and worker’s available time. To solve the routing problem we use an Ant Colony Optimization metaheuristic. We present some numerical results using a case study, in which the proposed method of this paper finds better results in comparison with the current method used in the case study.

This paper examines the spoke and hub location decisions in a routing problem. To minimize the total cost, the study analyzes on how to locate the spokes, hubs and the allocation of spoke nodes to hub nodes, the routing among the nodes and the number of vehicles assigned to each hub thoroughly. As there might be no facility assigned to some points, unsatisfied demands must be distributed to other nodes with available facilities. Furthermore, the realized demand is determined by considering the perceived utility of each path, using The Gravity rule. For this purpose, the proposed nonlinear model is transformed into a linear programming model, where some tightening rules and preprocessing procedures are applied, and also the sequential and integrated approaches are developed to solve the problem. In the sequential method, spokes are allocated, and hubs are selected based on the location of the spokes, after which the routing in the local tour is determined. Meanwhile, in the integrated approach, the aggregated model is solved. A heuristic is presented to address the integrated model. Numerical experiments are run on both approaches, to compare both, and obtain insights from the model.

In this study an integrated model is proposed for the location inventory routing problem under uncertainty. This problem involves determining the location of distribution centers (DCs) in a three echelon supply chain. The DCs receive orders from the customer and according to a continuous review inventory replenishment policy place orders to the supplier. The products are directly shipped from the supplier to the DCs. The vehicles start from the DCs to fulfill the demands of the customers. Determining the routing of the vehicles is one of the decisions involved in this problem. The demands of customers are stochastically distributed and the capacity of DCs are limited. If one of the DCs undergo a disruption and is unable to fulfill the demands of the customers, shortage may occur. Moreover in the proposed model the shortage is considered as partial backlogging. This means that if shortage occurs, some of the orders result in lost sales and other orders are fulfilled in the next period. In order to optimally solve the proposed model a nonlinear integer programming (INLP) model is developed. However, since the problem is NP-hard, the mathematical formulation cannot be efficiently solved for large sized instances of the problem. Therefore an outer approximation method is developed to solve the problem more efficiently. The computational results show the efficiency of the proposed method.

The Health Care system is changing from the hospitalization to the home care, and the World Health Organization has announced that the rate of care-dependent elderly people in Europe will considerably increase within the next decades. Thus, scientific planning for this area is an essential factor to improve the community health. This paper aims to develop a mathematical modeling for Home Health Care Routing and Scheduling Problem and to solve it by means of Simulated Annealing (SA) algorithm considering real condition (staff vehicle traveling, conditions of patients and so forth). We permit interdependent services for patients in which they can order as many services as they want with any relation between them (Multiple Services) and supposed time window for each service. The mathematical formulation of the problem is coded in GMAS software, which is a well-known commercial software for solving optimization problems. In addition, for large-scale problems where GAMS is unable to solve, SA algorithm is applied to tackle the problems. Finally, sensitivity analysis on the most important parameters (number of services and number of patients with interdependent Multiple services) are conducted. The results reveal that when each patient can order infinite services with any relation between them, complexity of the problem increases, but SA algorithm can solve large instances with reasonable solution in the less computational time. Thus, SA algorithm shows a rational performance for large instances. Moreover, the most important factors that affect the objective value and the run time of the problems are number of patients, and number of patients with interdependent multiple services.