The present study focused on the Taguchi experimental design technique of Friction Stir Welds of dissimilar aluminum alloys (AA2024-T6 and AA6351-T6) for tensile properties. Effect of process parameters, rotational speed, Traverse speed and axial force, on tensile strength was evaluated. Optimized welding conditions for maximize tensile strength were estimated in order to improve the productivity, weld quality. Non-linear regression mathematical model was developed to correlate the process parameters to tensile strength. The results were verified by conducting the confirmation tests at identified optimum conditions.