This study endeavors to evaluate the effectiveness of green distribution and green supply chain practices at PT Bio Farma (Persero) in relation to polio vaccine products. The ultimate objective is to establish and attain future green distribution targets. The research methodology utilizes the Green Supply Chain Operations Reference (Green SCOR) model and the Analytical Hierarchy Process (AHP) to analyze the production and distribution data of polio vaccine (OPV) and inactivated polio vaccine (IPV) products from January to December 2023. The performance values for each key component of Green Distribution and Green Supply Chain are as follows: Plan = 22.9, Source = 16.60, Make = 21.53, Deliver = 11.24, and Return = 7.08. The total performance value for Green Distribution and Green Supply Chain is 79.41. According to APICS standards, the performance of Green Distribution and Green Supply Chain is rated as “Good”. Future performance improvements will focus on supply chain and collaborative planning, establishing long-term partnerships with suppliers and customers, optimizing environmentally friendly transportation, and developing the enterprise information system. Our study proposes that the distribution and logistics managers at PT Bio Farma should persistently monitor and assess their operations to enhance the efficiency of their green distribution and green supply chains. By doing so, they can ensure the successful attainment of performance objectives for disseminating the polio vaccine in Indonesia. This research presents a significant advancement by incorporating the Green SCOR framework into the specific domain of polio vaccines, emphasizing sustainability and environmental efficiency. This approach paves the way for new avenues of investigation in green supply chain research and offers a novel viewpoint on how the pharmaceutical industry, specifically vaccine distribution, can utilize sustainable practices to enhance their operations while mitigating environmental ramifications.