This research aims to identify the Mediating role of ICT on the Impact of supply chain management (SCM) on organizational performance (OP), a field study: of pharmaceutical companies in Jordan. To achieve the aim of the research, the researcher used the descriptive analytical approach. The research population is all the employees in the three pharmaceutical companies listed on the Amman Stock Exchange (1,528), A suitable sample content of (400) employees was chosen, questionnaires were distributed using Google Forms, and the percentage of correct questionnaires was (85%), The research concluded that SCM with its dimensions has an impact on OP in pharmaceutical companies in Jordan, CRM does not exhibit a notable impact on the dependent variable OP and this research provides robust support for ICT mediating the relationship between SCM and OP in pharmaceutical companies in Jordan. The research recommended pharmaceutical companies to explore strategies to enhance their customer relationships and it also recommends pharmaceutical companies to invest in and enhance ICT infrastructure and capabilities, this research also recommends future studies to examine the role of artificial intelligence (AI) instead of (ICT) mediator between (SCM) and (OP).